A 23 year old woman developed sore throat, fever and swollen glands in her neck. The tonsils were enlarged with white spots on the surface. In about one week, the sore throat disappeared. Following an additional week, she noted her urine had become tea-colored. She presented to her physician and explained her condition for the past two weeks, the physician observed no abnormalities in the pharynx, but did find that she had an elevated blood pressure.
Examination of her urine revealed hematuria (increased blood in the urine) and substantial proteinuria. Evaluation of the patient’s serum revealed high titers to streptococcal antigens anti-streptolysin O and anti-DNase B.
Explain the role of the immune system (both protective and destructive) in this case.
Explain the physiological immunopathology associated with the patient’s condition.
Why is there blood and protein in the urine?
How would this disease affect complement levels in the patient’s serum?
What is the patient’s primary diagnosis based on the information provided?